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IGF-1 + SARMs (e.g., RAD-140, LGD-4033) A mild post-cycle protocol is recommended: DHEA 100 mg/day for 4 weeks ZMT Hormonal support and cortisol regulation Optional: Over-the-counter aromatase inhibitors if experiencing estrogen-related side effects For more on hormonal changes when stopping support compounds, read What Happens When You Stop Taking DHEA
Early studies in the 1980s and 1990s did show that sermorelin could increase growth velocity in certain children over short periods
Acetaminophen affects the sulfation pathway for estradiol
Pivotal Phase 3 trials Trial SURMOUNT-1 (NEJM 2022) Population 2,539 adults, obesity, no diabetes
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No SAEs were reported, and none of the AEs led to premature treatment discontinuation
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