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Freckles and moles begin darkening

Endocrinology 157 , 207219 (2016)

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This is a fundamental limitation of the enterprise: the arithmetic is exact, but its inputs are uncertain, so an exact calculation on an uncertain input yields an uncertain result dressed up in false precision

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Interestingly, the influence on RAAS should also be considered in the clinical practice during the screening of suspected hyperaldosteronism due to the interfering regulation of sodium and water balance or mimicking the effects of beta-blockers (SGLT2-i)