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Mitochondrial dynamics, including fusion and fission, respond to changes in the intracellular and extracellular environment by regulating mitochondrial size, number, and localization, thereby affecting both ROS production/clearance and organismal adaptive capacity

Interestingly, we found the upregulation of YBX1 and AMPK expression during human macrophage activation and polarization

This age-dependent decrease is further corroborated by recent large-scale observational data, which found significantly lower BChE values in COVID-19 patients aged 65 yearsa demographic that also represented nearly 96% of the cohorts total mortality 18,20

& Terman, M

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