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Clinicians should highlight dehydration risk and reinforce the importance of maintaining adequate fluid intake, especially as patients who experience nausea on GLP-1 medications may avoid consuming fluids. Clinicians should also use caution prescribing these medications in patients with diminished gastrointestinal motility

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Asc and GSH are localized in most of cell compartments such as cytoplasm, mitochondria, peroxisomes and chloroplasts, the Asc being additionally also found in the apoplast

Caffeine is known to relax the lower esophageal sphincter (LES), the muscle that acts as a valve between the esophagus and the stomach