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STEP 4: a cleaner continue versus stop test STEP 4 randomised people to continue semaglutide or switch to placebo after a 20-week run-in
Consultation Format: Asynchronous (Most Common): Complete detailed questionnaire online Provider reviews within 24-48 hours Responds with questions or approval Can message with questions Live Video/Phone: Scheduled appointment (15-30 minutes) Real-time discussion with provider Ask questions directly Decision made during visit What Provider Assesses: Eligibility for GLP-1 therapy Which medication is best for you Starting dose Contraindications Realistic expectations Commitment to treatment Step 4: Choose Your Medication Decision Framework: Choose Semaglutide If: Want excellent results at lowest cost Need to lose 20-50 pounds Budget is primary concern ($199/month) Have cardiovascular disease Choose Tirzepatide If: Want maximum results Need to lose 50+ pounds Can afford $349/month Want most effective medication Your provider will help you decide based on your goals, health status, and budget
tirzepatide targets two and is generally more potent for weight loss
Report any new joint symptoms promptly so they can be assessed and documented appropriately
Saneto, R
After several weeks of consistent dosing, semaglutide builds up to a steady-state concentration, meaning the low point between doses is higher than it was at the start
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