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These are typically temporary and often dose-dependent, meaning they can improve over time or with a dosage adjustment
doi:10.1007/978-94-010-0688-0_7 Billington RA, Travelli C, Ercolano E, et al
This work was supported by R35HL139726 (ESN), R01HL156670 (CCS), K24HL150630 (CCS), and 5R01HL157973 (SF)
Its primary mechanism involves binding to MC1R receptors in melanocytes, triggering increased production of eumelaninthe pigment responsible for darker skin tones
These include pancreatitis (inflammation of the pancreas) and gallbladder disease (including gallstones and cholecystitis), both of which are recognised warnings in the prescribing information for licensed GLP-1 receptor agonists such as semaglutide and tirzepatide