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However, he added that, in his opinion, a study comparing semaglutide with other meds to treat diabetes and heart failure would be helpful. Wright noted that [i]t now seems likely that cornerstone therapy for type 2 diabetic patients with obesity should be coadministration of an SGLT2 inhibitor and a GLP-1 receptor agonist, instead of the historic and perhaps now somewhat obsolete treatment with metformin and insulin. Whether their optimism is justified remains to be seen, but this study suggests that semaglutide could be an effective treatment for heart failure associated with diabetes.
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Yet, controversial outcomes on the efficacy of metformin have also been reported 21,22,23,24 , that might be attributed to heterogeneity of responses in some patient subgroups
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