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Tirzepatide has demonstrated cardiovascular safety with potential benefits including modest blood pressure reductions (3-7 mmHg), improved lipid parameters, and a small increase in resting heart rate (2-4 bpm)
In this study, 422 participants who lost over 5% of initial body weight on a low-calorie diet were randomized to liraglutide 3.0 mg or placebo for 56 weeks
Mechanick JI, Harrell R, Allende-Vigo MZ, Alvayero C, Arita-Melzer O, Aschner P, et al
The authors point out that other classes of drugs, including those treating erectile dysfunction and an anti-arrythmic drug, have previously been found to cause NAION in some patients
Interestingly, the effect of metformin on gut glucose utilisation is well known to radiologists, as metformin use will interfere with imaging by positron emission tomographycomputed tomography (PET-CT)
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