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Unlike some peptides where receptor downregulation requires cycling, GLP-1 receptors don't follow the same pattern

Moreover, CNS GIPR KO and mGIPR-Ab/GLP-1 treatment of wild-type mice both result in reduced activity in pathways associated with immune function, particularly neutrophil degranulation, suggesting that decreased CNS GIPR signalling might reduce obesity-associated inflammation 47,48,49

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The most commonly reported side effects are mild and tend to resolve within the first week of use

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