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The mechanistic consequence is that GHRP-6 activates the full biological program that ghrelin controls not just GH secretion, but somatostatin suppression, appetite signaling via NPY/AgRP pathways, gastric motility, and elements of the reward circuitry

Gut 60 , 618623 (2011)

Studies demonstrate high receptor selectivity with minimal effects on ACTH, cortisol, prolactin, or other pituitary hormonesdistinguishing it from other GH-releasing peptides

Over-the-counter supplements typically contain 102,000 micrograms per dosefar exceeding physiological requirements

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