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We previously produced the App NL-G-F/NL-G-F -KI ( App NL-G-F ) mouse strain using genomic DNA of introns 15 to 17 of mouse APP, which humanized the A sequence, and introduced KM670/671NL (Swedish), I716F (Iberian), and E693G (Arctic) mutations 41

Heres where vitamin B12 might come into play: Vitamin B-12 is a cofactor in the methylation cycle, meaning that it helps to activate methylation

FASEB journal : official publication of the Federation of American Societies for Experimental Biology , 34 (2), 32893304