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The medication is officially intended for clinically obese patients (body mass index, or BMI, over 30), or with a BMI over 27 and a weight-related health condition

In the pivotal SURMOUNT-1 trial involving adults without diabetes, participants receiving the highest dose (15 mg) lost an average of 20.9% of their body weight over 72 weeks, compared to 3.1% with placebo

When formal cardiovascular risk reduction is the explicit indication, semaglutide currently carries the established outcomes label

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