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Using the BioGRID database 26 as a reference, we find that interactions of 158 of these targets with human pathogenic viruses have been reported before, which represents a highly significant enrichment among reported interactions between enzymes and viruses (Fishers exact test p = 9.1 10 12 , odds ratio 1.93.4) and supports their central role in viral replication across diverse viruses

Presented for research literature review only Izumi Y et al

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12/15-lipoxygenase inhibition attenuates neuroinflammation by suppressing inflammasomes

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