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GLP-1 stimulates postprandial insulin secretion and reduces glucagon production from pancreatic cells
In one study, men with low testosterone who used TRT lost about 11 pounds of fat and gained about nine pounds of lean mass over 18 months
Sex Steroids Indirect effects on testosterone, estrogen, and progesterone occur via improved gonadotropin signaling and body composition
Neither has a clear tolerability advantage for the majority of patients
GLP-1s are designed to suppress appetite, but nursing mothers should be consuming more calories, not less, to support milk production
This upregulation during pathological states suggests a potential adaptive response that might enhance sensitivity to GLP-1 agonist therapy during heart failure
