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Heres what matters: Fast MAOA = low serotonin (the enzyme clears it too quickly) Slow MAOA = high serotonin (serotonin builds up and can spike symptoms) So your patients MAOA speed completely changes how they respond to mood treatments

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So in that 25 years, using frameworks like the phenotypes that you've actually studied, how much success were you able to have with lifestyle-focused treatments