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Longer-term use (6+ months) may create more durable improvements where enhanced dermal architecture supports ongoing collagen synthesis at rates intermediate between treatment peaks and pre-treatment baseline, potentially maintaining 40-60% of peak improvements indefinitely without continuous peptide application

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Weinberg, R.B., VanderWerken, B.S., Anderson, R.A., Stegner, J.E

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Used together, the two peptides appear to complement each other