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4 mg dose group : Mean weight reduction of approximately 17.3%
Although structurally and functionally unique, this compound has poor pharmacokinetic properties due to its electrophilic nature that preclude potential clinical development 33
Association of gut microbiome with hypertension (HTN) Hypertension is a significant worldwide public health concern and stands as the foremost risk factor for cardiovascular diseases, leading to a substantial economic burden on society
On the contrary, the positive effect of GIP on glucagon secretion is preserved [34]
References Cell Metabolism (2015) The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance (Lee C, Zeng J, Drew BG, et al.) Journal of Translational Medicine (2023) Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging (Wan W, Zhang L, Lin Y, et al.) Journal of Molecular Medicine (2019) MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction (Lu H, Wei M, Zhai Y, et al.) Nature Communications (2021) MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis (Reynolds JC, Lai RW, Woodhead JST, et al.) Frontiers in Physiology (2023) Role of MOTS-c in the regulation of bone metabolism (Yi X, Hu G, Yang Y, et al.)
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