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Furthermore, this substance is not approved for human clinical use by any global regulatory authority and it may lead to negative health effects
When mitochondrial damage occurs, PINK1 accumulates on the mitochondrial outer membrane and recruits the E3 ubiquitin ligase Parkin (Picca et al., 2023)
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In the previous section, we outlined the principle in animal models and humans, of how a primary biochemical disturbance of white matter can trigger a potentially important secondary autoimmune inflammatory response, and indeed, how these two phenomena almost universally co-exist
For these patients, oral B12 supplementation (1,000-2,000 mcg daily sublingual methylcobalamin) provides comparable B12 repletion without injection
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