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GSK-3 inhibition supports neuronal survival and may contribute to P21's antidepressant-like effects observed in animal models
Hypoglycemia is not expected but has been reported, most often in patients who are also using agents known to cause hypoglycemia, such as insulin or sulfonylureas
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This is the same additional pathway that tirzepatide uses beyond semaglutide
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Lower-dose signaling may influence these systems without triggering strong appetite suppression
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