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To view a copy of this licence, visit About this article Cite this article Quddos, F., Fowler, M., de Lima Bovo, A.C

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456 The I-SPY 2 umbrella trial precisely matches multiple novel agents or combination therapies to breast cancer molecular subtypes, enabling rapid assessment of early efficacy signals and adaptive optimization, thereby accelerating the development of precision treatments for high-risk breast cancer patients (NCT01042379)