Other research highlights: 30% of GLP-1 users tested positive for SIBO or IMO even after accounting for diabetes (5) GLP-1 medicines caused microbiome changes and altered metabolism in mice (6) GLP-1 medicines tested in humans only had noticeable microbiome changes by 48 weeks (7) Despite not necessarily having slower gut motility, one study found that 88.9% of obese patients had SIBO (8) A meta analysis of people with IBS symptoms, found that up to 78% of people had SIBO, many of whom were undiagnosed (9) Overall, Sun and colleagues (1) could not prove a mechanistic link between GLP-1 medications and SIBO, however they did find that SIBO was twice as likely in GLP-1 users
Second Natures medication programme combines Wegovy with structured nutrition guidance from registered dietitians and nutritionists, built around the balanced plate of half vegetables, a quarter protein, a quarter complex carbohydrates such as wholegrain bread, brown rice, or oats, plus a serving of fat
If semaglutide is not the right fit, our doctors will develop a plan that uses other evidence-based therapies and lifestyle interventions to support your success
Use sterile handling
If your symptoms persist or become more intense, do not hesitate to speak with your healthcare provider
Electronic health records with timestamped entries are the standard, and the EHR layer is the natural place where HIPAA-compliant software development principles meet day-to-day clinical documentation