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This is the data behind the muscle-and-nutrient concern, drawn from the largest claims analysis to date , Butsch and colleagues' retrospective study of 461,382 US adults newly prescribed GLP-1RAs (Butsch et al., Obesity Pillars, 2025

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At elevated temperatures, above 86 degrees Fahrenheit (30 degrees Celsius), hydrolysis can become significant within hours

Fixing that single variable restarted progress without any change to medication dosage, proving that GLP-1 creates the opportunity, but nutrition structure determines whether the scale actually moves

J Clin Anesth 2024:111693

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