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In certain cancers, such as NSCLC, TRAIL receptor signaling has been associated with a pro-tumorigenic inflammatory profile

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Rather paradoxically, it has also been highlighted that GSHand notably its catabolites, as originated by metabolism by gamma-glutamyltransferasecan promote oxidative processes, by participating in metal ion-mediated reactions eventually leading to formation of reactive oxygen species and free radicals

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doi: 10.1016/j.immuni.2017.03.019 53 FraternaleAPaolettiMFDominiciSBuondelmonteCCaputoACastaldelloAet al