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Given the clinical evidence reviewed above, patients with type 2 diabetes and/or obesity are the most promising candidate population to benefit from GLP-1RA-centered pharmacotherapy to improve cardiovascular and kidney outcomes

Studies in both humans and mice have shown that long-chain free fatty acids (LCFAs) increase GLP-1 secretion from taste cells, further reinforcing sucrose preference in a GLP-1 receptor-dependent manner (63, 64)

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Looking ahead hot off a major earnings beat and regulatory approval for its new weight loss pill, Lilly expects to file for the FDAs greenlight on retatrutide as early as this year

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