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Treatment with Pharmacological peroxisome proliferator-activated receptor agonist Clofibrate increases intestinal carnitine absorption in rats
The AWARD trials demonstrated preservation of kidney function in patients with type 2 diabetes, adding another dimension to its value beyond pure weight loss
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At the systemic level, GLP-1 RAs improve insulin sensitivity in peripheral tissues (muscle, adipose), reduce circulating free fatty acid flux to the liver, suppress hypothalamic appetite circuits to promote weight loss, and lower systemic pro-inflammatory cytokines (TNF-, IL-1, IL-6), thereby reducing the hepatic inflammatory milieu indirectly [7,26,30]
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