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In vitro , GSH-deficient hepatocytes show upregulated mRNA levels of DNA methyltransferase, Tet2, and Tet3, along with increased Dnmt activity (5-mC) and global DNA methylation levels
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This, in turn, leads to the formation of what is known as a leaky gut [110, 140]
This is where oxidative stress can occur if the body isn't equipped to move to the next step quickly
These mechanisms are further contextualized across major therapeutic modalities, supported by clinical trials
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