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The LEADER trial with liraglutide and the REWIND trial with dulaglutide did not show significant increases in retinopathy complications, though differences in trial design, patient populations, baseline retinopathy prevalence, and rates of glycemic improvement may explain these discrepant findings

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The study is structured to investigate multiple formulation variants across a large number of experimental arms, with a focus on pharmacokinetic performance, tolerability, and compatibility with novel peptide structures