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Pharmacol Res 1991;23:241-6
If you hold the dose for only 30 seconds instead of the recommended 2 to 5 minutes, you may absorb as little as 10 to 15% of the dose sublingually
This is why its often talked about in the context of muscle growth, fat metabolism, and tissue recovery
You struggled to manage your appetite even with higher doses
Interestingly, a longer duration of metformin treatment seems to improve survival, whereas, adding sulphonylureas to metformin has been demonstrated to attenuate its cardiovascular benefit (Lamanna et al., 2011)
Ann Intern Med 173(4):278286
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