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They did not observe a significant effect on rats weight or insulin levels

Advantages of Extended Drug Retention An extended elimination period offers multiple practical benefits: Consistent therapeutic action The medication maintains stable blood levels, preventing the highs and lows that can disrupt appetite control or metabolic regulation Weekly injection schedule Patients inject only once per week rather than daily, which significantly improves treatment adherence Dosing flexibility When a scheduled injection is delayed, residual drug activity provides a buffer period before therapeutic effects diminish Reduced fluctuation-related effects Gradual clearance minimizes the risk of sudden changes in drug concentration that could trigger adverse reactions This pharmacokinetic profile positions the medication alongside other long-acting therapies while incorporating a triple-receptor mechanism

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Briefly, 6 h after initiating fasting conditions (only fasted from food), FITC-dextran was gently administered via oral gavage to the rats at 40 mg/kg, 200 l body weight