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Clinical trials have demonstrated weight loss ranging from approximately 10% with GLP-1 agents at weight management doses (e.g., semaglutide 2.4 mg in the STEP trials) to over 20% with tirzepatide at higher doses (SURMOUNT trials)
The most common side effects of semaglutide use are gastrointestinal issues
The peptide particularly influences matrix metalloproteinases (MMPs) , enzymes that break down extracellular matrix components
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Unlike traditional GLP-1 drugs, tirzepatide targets both GLP-1 and GIP receptors, unlocking superior weight-loss results compared to semaglutide (OZEMPIC, WEGOVY)
