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doi: 10.3389/fphar.2021.632295

When pain medications are used repeatedly, foundational nutrients are gradually depletedoften without obvious early symptoms

For instance, in the last two decades, a number of studies suggest that PKCs, an integral part of Ras and MAPK signaling, are crucial factors in carcinogenesis and, depending on their levels in the cell, they either promote or suppress tumor cell growth and metastasis [122]

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