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IP3 stimulates Ca 2+ signaling and DAG acts through protein kinase C (PKC) leading to different cellular events, such as proliferation, growth and migration

Skin sensitivity or tingling may sometimes be described as sensory nerve sensitivity , where the nerves that carry touch, temperature or pain signals become more noticeable or reactive

To clarify this translational challenge, the following sections examine the specific mechanisms underlying the failure of conventional therapies and initial pan-IL-17A inhibitors, establishing a theoretical basis for emerging biomarker-driven stratification strategies

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