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It is called glucotoxicity previously, 126 however, we may call this phenomenon hyperglucotoxicity, as a normal glucose level is not toxic to islet cells

With pivotal data published in the New England Journal of Medicine, a missed head-to-head endpoint against Eli Lillys tirzepatide, and fresh diabetes results presented in June 2026, the CagriSema FDA review carries unusual complexity for a drug that has already reset expectations across the weight management field