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Lillys phase 2 retatrutide results published in The New England Journal of Medicine show the investigational molecule achieved up to 17.5% mean weight reduction at 24 weeks in adults with obesity and overweight | Eli Lilly and Company

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While adipose tissue reduction is therapeutically desirable, disproportionate loss of lean mass may lower resting energy expenditure, impair functional capacity, and potentially compromise long-term metabolic durability

Current research has shown that mild cognitive impairment in Parkinsons patients is associated with brain energy metabolism (23)