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The background rate of pancreatitis in the general population, especially among people with obesity and type 2 diabetes who use these medications, is already elevated by the underlying conditions themselves

The strategy was, therefore, to identify GLP-1 mimetic drugs with a molecular structure close enough to native GLP-1 to stimulate the GLP-1 receptor, but with alterations that enabled prolonged activity by, in particular, possessing resistance to breakdown by DPP-4 (Meier, 2012)

Fat is the most potent stimulator of the gastro-colonic reflex