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Furthermore, a clinical study revealed that oral AST supplementation provides protection against ultraviolet-induced skin injury (Figure 1, which illustrates ASTs modulation of key pathways such as Nrf2/ARE, PI3K/Akt, and NF-B in promoting neuroprotection

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Despite evidence of systemic iron and ROS accumulation in FRDA, whether neuronal loss is directly mediated by ferroptosis remains an open question requiring further mechanistic exploration

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In the peroxisome proliferator-activated receptor (PPAR)-induced COPD model, upregulation of GPX3 expression can reduce lung tissue damage caused by oxidative stress ( As mentioned earlier, the vast majority of GPX3 is secreted by the renal proximal convoluted tubules, so we speculate that the kidney may be a highly expressed organ of GPX3, and to test our hypothesis, we analyzed the GSE111159 dataset (This dataset mainly detects the gene sequencing of 10 tissues and organs of mouse kidney, liver, brain, lung, thymus, muscle, spleen, stomach, heart and testicle under physiological conditions to understand the gene expression of each tissue and organ) in the GEO database (Gene Expression Omnibus, We found that GPX3 had the highest level of expression in kidney tissue under mouse physiology (Figure 3A), which is consistent with the results of the analysis by Kim et al

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