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MAPK signaling contributes to therapeutic resistance by enhancing the expression of drug efflux transporters such as MDR1 and P-gp and by upregulating antiapoptotic genes such as Bcl-2

Unopened vials stored at room temperature are typically stable for 2-3 years (check the expiration date)

The 1:1 mass ratio (5mg each) in this vial provides approximately 3.5 nmol of BPC-157 for every 1 nmol of TB-500, reflecting the molar ratios used in the majority of combination research protocols