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For larger botanical molecules, specialized carrier systems are needed to get through the skin barrier effectively
BMI of 30 or higher qualifies outright
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Bioorg Med Chem
This makes it particularly relevant in clinical contexts where someone has gut lining compromise alongside systemic inflammation, for example, long-term NSAID use for chronic pain
As with other GLP-1 medicines, people with: A history of severe gastrointestinal disease Pancreatitis Significant kidney or liver issues should only use GLP-1 treatments under close clinical monitoring
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