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Gastrointestinal adverse events and other safety issues have hindered the development of some GLP-1/glucagon co-agonist candidates, and several (e.g
The first month of Wegovy usage is usually based on helping the body get used to the medicines effects and hence prominent weight loss is not observed however an overall weight loss of 2-4% is common during this time
Contact your GP or diabetes specialist nurse if : Symptoms persist beyond four weeks despite dietary modifications Symptoms worsen rather than improve over time You experience severe or persistent nausea and vomiting , which may indicate severe delayed gastric emptying There is unintentional weight loss beyond expected therapeutic effects You develop persistent abdominal pain , particularly in the upper abdomen Burps are accompanied by diarrhoea lasting more than 48 hours or signs of dehydration You notice blood in vomit or stools, or black, tarry stools (seek urgent medical attention) You develop right upper abdominal pain with or without fever/jaundice , which could indicate gallbladder problems If you cannot contact your GP and need urgent advice, call NHS 111
Zepbound is the exact same medication as Mounjaro, but it is branded specifically for chronic weight management
People with specific health conditions or on medications should consult a healthcare provider before use
Compounded tirzepatide is usually supplied concentrated for exactly this reason
