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Dose-dependent associations existed between L-carnitine levels and risk of coronary artery disease, peripheral artery disease, and CVD but only in participants with concurrently high TMAO levels [3][7][36]

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Titration was started slowly for the first two patients, from 1 mg d 1 up to 10 mg d 1 and then up to 50 mg d 1 with concentrations of 10 mg ml 1 , and then from 54 mg d 1 up to 90 mg d 1 with a concentration of 50 mg ml 1