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Dose-related effects on the rat fetus (structural abnormalities and reduced body weight) occurred only at higher dosages, equal to or greater than 150 mg/kg (more than 2344-times the 10 mg clinical dose, based on AUC), which were associated with maternal toxicity
Li J, Tang Y, Cai D
For KPV, the effect is driven by PepT1-mediated cellular uptake, not by circulating levels, which is why no formal plasma half-life exists Dalmasso et al., 2008
a growing body of evidence has indicated that U0126 exerts its antioxidative activity through the MAPK/ERK-independent pathway 37
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In most cases, mild skin reactions subside on their own without any intervention
