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Evidence: GLP-1 Medications and Cholesterol Semaglutide and Tirzepatide Earlier GLP-1s like semaglutide and dual agonists like tirzepatide already showed modest improvements in lipid profiles: LDL cholesterol reduction by 510% Triglyceride reduction by 1520% Mild HDL increase These effects were partly due to weight loss , but researchers suspected other mechanisms were at play