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GLP-1R as a Target for Diabetes and Other Diseases Type 2 diabetes also known as adult-onset diabetes is the most common form of diabetes in human populations, estimated to affect over 450 million individuals, corresponding to over 6% of the worlds population

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SURPASS-2 showed tirzepatide was superior to semaglutide 1mg for both A1C reduction (2.09% vs 1.86%) and weight loss (12.4% vs 6.2%) at the 15mg dose, establishing the clinical relevance of dual-agonism over selective GLP-1 agonism

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