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Study Overview A total of 314 patients were randomized (1:1) to receive either the test semaglutide or the reference semaglutide injection
In the SURPASS-2 head-to-head against semaglutide for diabetes, tirzepatide produced significantly greater A1c reductions
Polypharmacology: challenges and opportunities in drug discovery
Call 999 or go to your nearest A&E immediately if you experience: Signs of a severe allergic reaction (anaphylaxis), including swelling of the face, lips, tongue, or throat, difficulty breathing, or a widespread rash with collapse Seek urgent medical advice if you experience: Severe or persistent vomiting that prevents you from keeping fluids down Signs of dehydration, including dizziness, dark urine, or significantly reduced urination Severe abdominal pain, particularly if it radiates to the back this may indicate pancreatitis, a rare but serious adverse effect associated with GLP-1 receptor agonists [11] [12] Pain in the upper right abdomen, fever, yellowing of the skin or eyes (jaundice), pale stools, or dark urine these may be signs of a gallbladder problem, such as gallstones or cholecystitis, which have been associated with this class of medicine and with rapid weight loss Symptoms of hypoglycaemia (low blood sugar), such as shakiness, sweating, confusion, or palpitations the risk is higher if you are also taking insulin or a sulfonylurea
The cost of syringes is small
