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Formulation factors including pH, penetration enhancers, and stability protection are important considerations

Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice

They are synthesized by most liver cells as well as by infiltrating immune cells and their effects depend on their local concentrations at the site of injury (Sahin et al., 2010)