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Histological examinations revealed that diabetic rats exhibited segmental thickening of the glomerular basement membrane, mesangial matrix expansion, hypercellularity, distorted tubules, and inflammatory infiltration

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This chemical framework, seldom seen in clinical practice, provides enhanced metabolic stability, allowing the compound to survive the digestive tract and achieve significant oral bioavailability

TRIUMPH-4 (28.7% weight loss, knee OA population, December 2025), TRIUMPH-1 (28.3%, general obesity, May 2026), TRANSCEND-T2D-1 (-2.0% HbA1c, 16.8% weight loss, June 2026), TRIUMPH-2 (20.8% weight loss, obesity + diabetes, July 23, 2026), and TRIUMPH-3 (22.6% weight loss, obesity + cardiovascular disease, July 23, 2026) have all reported positive results

Paeoniflorin alleviates depression by inhibiting the activation of NLRP3 inflammasome via promoting mitochondrial autophagy