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Clinical evidence from the STEP trials demonstrated that higher doses produce greater weight loss, with the 2.4 mg dose resulting in approximately 15% body weight reduction over 68 weeks compared to placebo

doi: 10.3390/nu16152496 87 SiezenR

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Symptoms include nausea, diarrhea, vomiting and constipation, occurring twice as often as patients treated with placebo

Cureus 16:e51788