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Diabetes 68 (1), 2133 (2019)
If youre pregnant, planning to become pregnant, or breastfeeding, talk to your doctor about alternative weight management options
However, the optimal wearing time would be determined by the specific product design, drug formulation, and delivery technology, and would be clearly specified in any future product's Patient Information Leaflet (PIL) if approved
Larger Phase 3 trials the TRIUMPH programme (registered on ClinicalTrials.gov) are currently underway to evaluate retatrutide across broader populations, including individuals with type 2 diabetes and cardiovascular disease
For those who require assistance, the upper arm may be a suitable option, but its important to have another person administer the injection if the patient cannot comfortably reach this area themselves
The EMPA-REG OUTCOMES trial showed that empagliflozin, a SGLT-2i, markedly reduced the risk for HF hospitalization relative to the placebo ( HR = 0.65, 95% CI 0.500.85, P = 0.002) [96]
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