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Bupropion is contraindicated in patients with seizure disorders, eating disorders (current or historical), abrupt discontinuation of alcohol or sedatives, or those taking monoamine oxidase inhibitors (MAOIs)

However, combining medication with regular physical activity helps preserve muscle mass, improves cardiovascular health, and enhances long-term weight maintenance

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In my experience, approximately 95% of stalled progress cases trace to identifiable external factors rather than medication tolerance

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Most adverse events were mild and consistent with the established safety profile of semaglutide