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Research has documented MT-IIs potent, dose-dependent pro-erectile effects in rodent, rabbit, and non-human primate models , with studies characterising ex copula erection frequency, latency to erection, and duration of response following MT-II administration at doses producing reliable and reproducible pro-erectile responses

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By engaging these systems, Melanotan 2 may alter the functional connectivity of cortical and subcortical networksregions including, for instance, the anterior cingulate cortexwhere oxytocin receptor distribution may differ in atypical neurodevelopmental contexts

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This includes starting with big doses, then keeping up with smaller ones

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